Professor, Microbiology & Molecular Genetics
School of Medicine
Joint Appointment, Pharmaceutical Sciences
School of Medicine
Ph.D., University of Naples, 1979
Phone: (949) 824-3875, 46738
Fax: (949) 824-0074
Email: borrelli@uci.edu
University of California, Irvine
Microbiology and Molecular Genetics
308 Sprague Hall
Mail Code: 4049
Irvine, CA 92697
dopaminergic neurons, pharmacology, animal models, neurological and neuropsychiatric diseases
Nomination to Member of the European Molecular Biology Organization (EMBO) (1997)
Prix de la Fondation de la Recherche Médicale, Paris (2001)
Prix Mercier-Bourdeix de l’Académie des Sciences Françaises (2001)
Prix INSERM in Physiopathology (2002)
Umesono Lecture Award, The Salk Institute (2014)
Chancellor’s Professor, University California Irvine, (2017)
Knight of the Legion of Honor, France (2017)
Golgi Award (2017)
IIC Los Angeles Creativity Award (2018)
Athalie Clarke Award (2018)
Dopamine is a central neuromodulator of the CNS. Dysfunctions of dopaminergic homeostasis leading to either low or high dopamine levels are causally linked to Parkinson’s disease, schizophrenia, addiction and endocrine tumors. Studies conducted at the molecular, cellular and behavioral levels aim to uncover the molecular mechanisms by which dopamine receptor’s signaling controls neuronal functions and behavior. Genetically engineered mice (knock-out mice) constitute our experimental models in which we analyze how altered or abolished expression of dopamine receptors in specific neurons affects physiological responses. A particular interest is devoted to the analysis of dopamine-mediated effects on motor control and addiction to drugs of abuse. These studies are relevant to the understanding of human neurological and neuropsychiatric disorders.